ceesdekker.net Secrets
ceesdekker.net Secrets
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Rotary motion of DNA rotors on nanopores. Major row: raw online video on the Cy5 channel of each rotor. Center row: corresponding one-particle localization final results of both finishes of the DNA rotors. The situation of the current body is marked as orange and blue dots, as well as the trajectory of The ten frames just before the current frame is revealed as sound strains.
Human Rad51 filaments on double- and single-stranded DNA: correlating frequent and irregular varieties with recombination operate.
Round the very same time, the group of Paul McEuen, who was then centered for the University of California, Berkeley, confirmed comparable results on ropes of bundled nanotubes. Based on the wrapping angle, nanotubes can are available metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed using scanning tunnelling spectroscopy experiments.
Non-equilibrium folding of specific DNA molecules recaptured as many as one thousand situations in a good point out nanopore
2010, developed a brand new way (‘wedging transfer’) to control nanostructures; to start with report of DNA translocation through graphene nanopores; and realized hybrid nanopores by directed insertion of α-hemolysin into sound-condition nanopores
Microbiology has only been around for your century, considering the fact that we began to study micro-organisms much more critically. I thought nanobiology was an proper phrase, due to the fact all molecular Organic suitable interactions occur for the nanoscale: a protein is some nanometres in size, DNA is 2 nm thick.’
‘At the outset we checked out biological programs which has a physical look at and acted on The premise of the equipment we understood. It took a number of years prior to we commenced Performing more on the big biological troubles. I then began to contact it nanobiology, a phrase that did not exist at enough time.
2011, very first in vitro measurements of transport across only one biomimetic nuclear pore elaborate; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the system of homology recognition in DNA homologous recombination
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There was one particular challenge though — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers had been truly not these kinds of good conductors, which was somewhat disappointing. We So broadened our perspective to test to uncover extra promising molecules.
Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with research from scientific tests of DNA loop extrusion and supercoiling to DNA translocation by means of cees dekker nanopores. More not long ago his analysis has centered on learning chromatin composition and cell division with micro organism on chip, although he is usually trying to finally Create artificial cells from the bottom up.
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As an example, we look at the nucleopore complex, a gateway concerning the cell nucleus and the cytoplasm. This is a really challenging method and therefore challenging to examine in a very mobile, so we use biomimetics. We reconstruct holes and afterwards insert personal elements with the nucleopore intricate to study transportation by way of it at The only-molecule level.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever layout in 2005. (nl)